Newer Link Between Throat Cancer and Obesity

Scientist from both Massachusetts General Hospital and the Dana Faber have published a new study in the science journal Nature supporting a link between obesity, high acidity in the throat and throat cancer. This lead the team to looking at the portion of the lower "swallowing tube" (esophagus) that connects directly to the stomach. The tissue appears like in glandular tissue and cancers rising there are called Adenocarcinoma. This cancer appears to be different in the fact it is not so much associated with smoking tobacco products or drinking alcohol as it does with cancers from the upper section of the throat. Instead high acid production makes changes in the throat. Scientist have noted that there is a DNA difference as well as anatomical difference in these cells. At the junction where the esophagus meets the stomach exists a sphincter that tightens to block reflux of the stomach's acid back into the throat. The high level of abdominal fat onto this region may push stomach contents and acid back up into the throat. There is fat that that exists in 3 different compartments in the abdomen. That which exists right below the dermis(extra-peritoneal), that which exists in between obdominal organs or intraperitoneal may actually play a more important factor in obesity linked to heart disease and the mesentery fat. Men who have this higher leel of abdominal fat are called the "apple" shape (android) as opposed to those who have a predominance of fat on their hips as found mostly in women and is called gynecoid shape. The acid reflux can cause mutations seen in the DNA. Even earlier studies have found anomalies in this region of the esophagus called Barrett's Esophagus. Other aspects of this linked need to be looked as such as do these individuals who are predominantly male also for example wear tighter pants, do they tend to recline after eating meals, do they prefer certain hgih acid foods, are they more anxiety proned or depressed? These confounding or compounding factors also could play a secondary role to this phenomenom now noted. The bottomline is that obesity is associated with a legion of chronic illnesses and that it lies at the root of the majority of chronic illnesses in the USA. By reducing BMI(body mass index) a large number of diseases and and high health costs. A national program within the current healthcare system needs to become a part of implementing prevention particularly of overweight-obesity complex and the diseases associated with them.

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